IL-15 regulates immature B-cell homing in an Ly49D-, IL-12 , and IL-18 dependent manner.
Blood
; 111(1): 50-9, 2008 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-17901247
ABSTRACT
To complete their maturation and participate in the humoral immune response, immature B cells that leave the bone marrow are targeted to specific areas in the spleen, where they differentiate into mature cells. Previously, we showed that immature B cells actively down-regulate their integrin-mediated migration to lymph nodes or to sites of inflammation, enabling their targeting to the spleen for final maturation. This inhibition is mediated by IFN-gamma, which is transcribed and secreted at low levels by these immature B cells; IFN-gamma expression is extinguished following B-cell maturation. Stimulation of the MHC class I receptor, Ly49D, triggers a signaling cascade that increases transcription of both IL-12 (p40) and IL-18; these, in turn, induce the secretion of IFN-gamma. In the present study, we demonstrate that Ly49D-dependent secretion of IL-12 and IL-18 induces IL-15 expression by immature B cells, and that these 3 factors together regulate IFN-gamma production that inhibits their ability to home to the lymph nodes or to sites of inflammation. Thus, IL-15 controls immature B-cell homing, resulting in shaping the B-cell repertoire to enable an efficient immune response.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Antígenos Ly
/
Interleucina-15
/
Interleucina-18
/
Lectinas Tipo C
/
Subunidade p40 da Interleucina-12
/
Células Precursoras de Linfócitos B
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article