Nuclear survivin has reduced stability and is not cytoprotective.
J Biol Chem
; 283(6): 3289-3296, 2008 Feb 08.
Article
em En
| MEDLINE
| ID: mdl-18057009
ABSTRACT
Survivin is an essential mitotic protein that is overexpressed in many cancers, and its presence is correlated with increased resistance to radiation and chemotherapy. Here we demonstrate that sending survivin into the nucleus accelerates its degradation in a cdh1-dependent manner, abolishes the radio resistance normally conferred to cells by its overexpression, and prevents survivin from inhibiting apoptosis without affecting its mitotic localization. Our data suggest that targeting survivin to the nucleus provides an efficient means of eliminating it from the cell and may prove a novel strategy in cancer treatment, particularly in combination with radiotherapy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Regulação Neoplásica da Expressão Gênica
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Núcleo Celular
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Proteínas Associadas aos Microtúbulos
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Proteínas de Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article