[Study of anticoagulant activity of ethanol extracts from leech in vitro].
Zhong Yao Cai
; 30(8): 909-11, 2007 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-18074833
ABSTRACT
OBJECTIVE:
To study the anticoagulant activity of different portions of leech ethanol extracts (LEEs).METHODS:
Anticoagulant activity was determined by measuring prothrombin time(PT), thrombin time (TT), activated partial throboplstin time (APTT) and fibrinogen coagulation time (FCT).RESULTS:
PT, TT, APTT and FCT were remarkably prolonged by ethyl acetate portion of LEEs. Portions of petroleum ethrer, n-butanol and water extracted from LEEs was much weaker on anticoagulant activity.CONCLUSION:
The anticoagulant effect of ethyl acetate extract portion of LEEs is the strongest among the four portions, and this results may be from its inhibitory effect on thrombin-catalyzed fibrinogen hydrolysis.
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Base de dados:
MEDLINE
Assunto principal:
Coagulação Sanguínea
/
Materia Medica
/
Sanguessugas
/
Anticoagulantes
Limite:
Animals
/
Humans
Idioma:
Zh
Ano de publicação:
2007
Tipo de documento:
Article