Early phosphatidylinositol 3-kinase/Akt pathway activation limits poliovirus-induced JNK-mediated cell death.
J Virol
; 82(7): 3796-802, 2008 Apr.
Article
em En
| MEDLINE
| ID: mdl-18216097
ABSTRACT
Poliovirus (PV)-induced apoptosis seems to play a major role in tissue injury in the central nervous system (CNS). We have previously shown that this process involves PV-induced Bax-dependent mitochondrial dysfunction mediated by early JNK activation in IMR5 neuroblastoma cells. We showed here that PV simultaneously activates the phosphatidylinositol 3-kinase (PI3K)/Akt survival signaling pathway in these cells, limiting the extent of JNK activation and thereby cell death. JNK inhibition is associated with PI3K-dependent negative regulation of the apoptosis signal-regulating kinase 1, which acts upstream from JNK in PV-infected IMR5 cells. In poliomyelitis, this survival pathway may limit the spread of PV-induced damage in the CNS.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Apoptose
/
Fosfatidilinositol 3-Quinases
/
Poliovirus
/
Proteína Oncogênica v-akt
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article