Vasoconstrictor effect of acetylcholine in veins of the liver.
Bull Exp Biol Med
; 143(3): 291-4, 2007 Mar.
Article
em En
| MEDLINE
| ID: mdl-18225744
ABSTRACT
Intraportal acetylcholine administered to narcotized rats produced atropine-resistant constriction of hepatic veins, which was considerably prevented by phentolamine. Sodium nitroprusside produced a vasodilator effect. Similar results were obtained on isolated venous strip from the portal vein acetylcholine-induced contraction was reduced by 25-50% in the presence of nicotinic receptor antagonist tubocurarine and cholinergic agonist nicotine and by 10% in the presence of tetrodotoxin. Probably, acetylcholine stimulates synthesis and release of a vasoconstrictor transmitter via nicotinic receptors of endothelial cells and/or portal vascular wall nerve terminals.
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Base de dados:
MEDLINE
Assunto principal:
Veia Porta
/
Vasoconstrição
/
Acetilcolina
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article