[New drugs; pegaptanib and ranibizumab]. / Nieuwe geneesmiddelen; pegaptanib en ranibizumab.
Ned Tijdschr Geneeskd
; 152(2): 82-4, 2008 Jan 12.
Article
em Nl
| MEDLINE
| ID: mdl-18265796
ABSTRACT
The neovascular ('wet') form of age-related macular degeneration (AMD) is characterized by vascular growth and leakage in the retina. Two new drugs, pegaptanib and ranibizumab, have been shown to improve vision or slow the progression of AMD. Both drugs inhibit the action of vascular endothelial growth factor--pegaptanib as an oligonucleotide and ranibizumab as a monoclonal antibody--thereby decreasing angiogenesis in the eye. Adverse effects are associated with the intravitreal administration of both drugs and include increased intraocular pressure, local bleeding, and infection.
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Base de dados:
MEDLINE
Assunto principal:
Acuidade Visual
/
Aptâmeros de Nucleotídeos
/
Degeneração Macular
/
Anticorpos Monoclonais
Limite:
Humans
Idioma:
Nl
Ano de publicação:
2008
Tipo de documento:
Article