Selective cell adhesion inhibitors: Barbituric acid based alpha4beta7--MAdCAM inhibitors.
Bioorg Med Chem Lett
; 18(7): 2509-12, 2008 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-18331794
ABSTRACT
A novel series of barbituric acid derivatives were identified as selective inhibitors of alpha4beta7 MAdCAM (mucosal addressin cell adhesion molecule-1) interactions via a high throughput screening exercise. These inhibitors were optimized to submicromolar potencies in whole cell adhesion assays, retaining their selectivity over alpha4beta1 VCAM.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Barbitúricos
/
Integrinas
/
Adesão Celular
/
Mucoproteínas
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article