Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators.

Guo, Liangqin; Ye, Zhixiong; Ujjainwalla, Feroze; Sings, Heather L; Sebhat, Iyassu K; Huber, John; Weinberg, David H; Tang, Rui; MacNeil, Tanya; Tamvakopoulos, Constantin; Peng, Qianping; MacIntyre, Euan; van der Ploeg, Lex H T; Goulet, Mark T; Wyvratt, Matthew J; Nargund, Ravi P

Guo, Liangqin; Ye, Zhixiong; Ujjainwalla, Feroze; Sings, Heather L; Sebhat, Iyassu K; Huber, John; Weinberg, David H; Tang, Rui; MacNeil, Tanya; Tamvakopoulos, Constantin; Peng, Qianping; MacIntyre, Euan; van der Ploeg, Lex H T; Goulet, Mark T; Wyvratt, Matthew J; Nargund, Ravi P.

Afiliação

Guo L; Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, PO Box 2000, RY 50G-332, Rahway, NJ 07065, USA. liangqin_guo@merck.com

Bioorg Med Chem Lett ; 18(11): 3242-7, 2008 Jun 01.

Article em En | MEDLINE | ID: mdl-18479920

ABSTRACT

ABSTRACT

Discovery of a series of tert-butyl pyrrolidine derived, potent and orally bioavailable melanocortin receptor subtype-4 (MC4R) selective modulators is disclosed.

Assuntos

Pirrolidinas/síntese química; Pirrolidinas/farmacocinética; Receptor Tipo 4 de Melanocortina/agonistas; Administração Oral; Humanos; Estrutura Molecular; Estereoisomerismo; Relação Estrutura-Atividade; Telomerase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirrolidinas / Receptor Tipo 4 de Melanocortina Limite: Humans Idioma: En Ano de publicação: 2008 Tipo de documento: Article

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