[Mapping of pathogenic genes in two families with autosomal dominant ichthyosis vulgaris].
Yi Chuan
; 30(7): 843-50, 2008 Jul.
Article
em Zh
| MEDLINE
| ID: mdl-18779126
ABSTRACT
To localize the pathogenic genes of autosomal dominant ichthyosis vulgaris, we ascertained two ichthyosis vulgaris families from Hunan Province. Venous blood samples were collected from affected and unaffected family members and genomic DNA was extracted. We then performed genome scan and linkage analysis using microsatellite markers around known ichthyosis vulgaris loci in chromosomes 1 and 10. In family 1, the locus linked to ichthyosis vulgaris was located near D1S498 (1q21), which overlapped with known ichthyosis vulgaris loci. In family 2, however, all known loci for ichthyosis vulgaris were excluded and the new locus remains to be identified.
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Base de dados:
MEDLINE
Assunto principal:
Ictiose Vulgar
/
Mapeamento Cromossômico
Limite:
Female
/
Humans
/
Male
Idioma:
Zh
Ano de publicação:
2008
Tipo de documento:
Article