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Assessment of low prostate weight as a determinant of a higher positive margin rate after laparoscopic radical prostatectomy: a prospective pathologic study of 1,500 cases.
Chu, Peiguo G; Lau, Sean K; Weiss, Lawrence M; Kawachi, Mark; Yoshida, Jeffrey; Ruel, Christopher; Nelson, Rebecca; Crocitto, Laura; Wilson, Timothy.
Afiliação
  • Chu PG; Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA. pchu@coh.org
Surg Endosc ; 23(5): 1058-64, 2009 May.
Article em En | MEDLINE | ID: mdl-18813992
ABSTRACT

BACKGROUND:

The assessment of prostate weight as a determinant of a high prostate margin rate after laparoscopic radical prostatectomy has not been studied.

METHODS:

Prospective pathologic findings of 1,500 patients who underwent laparoscopic radical prostatectomy (LRP, 399 cases) and da Vinci prostatectomy (DVP, 1,101 cases) between December 2000 to June 2006 at City of Hope National Medical Center were evaluated. Gleason score, pathologic stage, the presence or absence of positive margins, extraprostatic tumor extension, and seminal vesicle involvement by tumor were recorded in all patients. Preoperational serum prostate specific antigen (PSA) levels were recorded in all but 13 cases. These parameters were then correlated with prostate weight.

RESULTS:

Of 1,500 patients, 345 had one or more positive margins (23%). Patients with low median prostate weight (49 g) had a significantly higher positive margin rate (p < 0.0001) and incidence of extraprostatic extension by tumor (p = 0.04), and were 1.523 times more likely to have positive margins [95% confidence interval (CI) 1.167-1.985].

CONCLUSION:

We conclude that low prostate weight may be a determinant of a higher recurrence rate and more aggressive disease.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Próstata / Prostatectomia / Neoplasias da Próstata / Recidiva Local de Neoplasia Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Humans / Male / Middle aged Idioma: En Ano de publicação: 2009 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Próstata / Prostatectomia / Neoplasias da Próstata / Recidiva Local de Neoplasia Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Humans / Male / Middle aged Idioma: En Ano de publicação: 2009 Tipo de documento: Article