Lookup table-based inverse model for determining optical properties of turbid media.
J Biomed Opt
; 13(5): 050501, 2008.
Article
em En
| MEDLINE
| ID: mdl-19021373
ABSTRACT
We present a lookup table (LUT)-based inverse model for determining the optical properties of turbid media from steady-state diffuse reflectance spectra that is valid for fiber-based probe geometries with close source-detector separations and tissue with low albedo. The lookup table is based solely on experimental measurements of calibration standards. We used tissue-simulating phantoms to validate the accuracy of the LUT inverse model. Our results show excellent agreement between the expected and extracted values of the optical parameters. In addition, the LUT represents a significant improvement in accuracy at short source-detector separations (300 microm) and low albedo (approximately 0.35). We also present in vivo data from clinically normal and malignant nonmelanoma skin cancers fit to the LUT-based model.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fotometria
/
Neoplasias Cutâneas
/
Análise Espectral
/
Algoritmos
/
Modelos Biológicos
/
Modelos Químicos
/
Nefelometria e Turbidimetria
Tipo de estudo:
Diagnostic_studies
/
Guideline
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article