Mast cell production of IL-4 and TNF may be required for protective and pathological responses in gastrointestinal helminth infection.
Mucosal Immunol
; 1(2): 147-55, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-19079172
ABSTRACT
Expulsion of the gastrointestinal nematode Trichinella spiralis is associated with Th2 responses and intestinal inflammation, which correlate with a marked mast cell (MC) response. To address the role of MC-derived cytokines in the induction of protective responses, WBB6F1-KitW/KitW-v (W/W(v)) mice were reconstituted with wild-type, tumor necrosis factor (TNF)-alpha(-/-), or interleukin (IL)-4(-/-) bone marrow (BM) prior to infection with T. spiralis. W/W(v) mice reconstituted with TNF-alpha(-/-) or IL-4(-/-) BM expelled the parasite less efficiently and showed diminished enteropathy, whereas protective responses were normal in W/W(v) mice reconstituted with wild-type BM and were accompanied by intestinal pathology. MC responses were reduced in W/W(v) mice reconstituted with IL-4(-/-) BM and to a lesser extent when reconstituted with TNF-alpha(-/-). These results suggest that MC-derived IL-4 and TNF may regulate the induction of protective Th2 responses and intestinal inflammation associated with the expulsion of T. spiralis. Significantly, these studies suggest a role for MC-derived cytokines as autocrine growth factors.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Triquinelose
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Interleucina-4
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Fator de Necrose Tumoral alfa
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Trichinella spiralis
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Células Th2
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Enteropatias Parasitárias
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Mastócitos
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article