Synthesis of novel conjugates of tetraoxane endoperoxide with bis(quaternary ammonium salts).
Biosci Biotechnol Biochem
; 73(1): 217-20, 2009 Jan.
Article
em En
| MEDLINE
| ID: mdl-19129629
ABSTRACT
Novel water-soluble conjugates of 1,2,4,5-tetraoxane bis(quaternary ammonium salts) were synthesized in a relatively stable crystalline form via four steps starting from methyltrioxorhenium-catalyzed endo-peroxidation of ethyl 4-oxocyclohexanecarboxylate with hydrogen peroxide in hexafluoro-2-propanol. The assay for the in vitro toxicity of water-soluble tetraoxanes 5a-5d to malaria parasites indicate that they were inactive against the Plasmodium falciparum FCR-3 strain.
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Base de dados:
MEDLINE
Assunto principal:
Tetraoxanos
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article