Prophylactic effect of glyceryl trinitrate on post-endoscopic retrograde cholangiopancreatography pancreatitis: a randomized placebo-controlled trial.
World J Gastroenterol
; 15(3): 366-8, 2009 Jan 21.
Article
em En
| MEDLINE
| ID: mdl-19140238
ABSTRACT
AIM:
To examine the prophylactic effect of glyceryl trinitrate on post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis and hyperamylasemia.METHODS:
Patients scheduled for ERCP were randomly divided into study group and placebo group. Patients in study group and placebo group were treated with 5 mg glyceryl trinitrate and 100 mg vitamin C, respectively, 5 min before endoscopic maneuvers.RESULTS:
A total of 74 patients were enrolled in the final analysis. Post-ERCP pancreatitis occurred in 3 patients (7.9%) of the study group and 9 patients (25%) in the placebo group (P = 0.012). Hyperamylasemia occurred in 8 patients of the study group (21.1%) and 13 patients (36.1%) of the placebo group (P = 0.037).CONCLUSION:
Glyceryl trinitrate before ERCP can effectively prevent post-ERCP and hyperamylasemia.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pancreatite
/
Placebos
/
Colangiopancreatografia Retrógrada Endoscópica
/
Nitroglicerina
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article