Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c.
Nat Immunol
; 10(3): 289-96, 2009 Mar.
Article
em En
| MEDLINE
| ID: mdl-19169261
ABSTRACT
Despite advances in the identification of lymphoid-restricted progenitor cells, the transcription factors essential for their generation remain to be identified. Here we describe an unexpected function for the myeloid oncogene product Mef2c in lymphoid development. Mef2c deficiency was associated with profound defects in the production of B cells, T cells, natural killer cells and common lymphoid progenitor cells and an enhanced myeloid output. In multipotent progenitors, Mef2c was required for the proper expression of several key lymphoid regulators and restriction of the myeloid fate. Our studies also show that Mef2c was a critical transcriptional target of the transcription factor PU.1 during lymphopoiesis. Thus, Mef2c is a crucial component of the transcriptional network that regulates cell fate 'choice' in multipotent progenitors.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fatores de Regulação Miogênica
/
Linfopoese
/
Células Progenitoras Linfoides
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article