[Combined indicators for diagnosing immune thrombocytopenic purpura].
Sichuan Da Xue Xue Bao Yi Xue Ban
; 39(6): 1000-3, 2008 Nov.
Article
em Zh
| MEDLINE
| ID: mdl-19253846
ABSTRACT
OBJECTIVE:
To search for the best combined indicators for diagnosing immune thrombocytopenic purpura (ITP).METHODS:
Reticulated platelet (RP), thrombopoietin (TPO), platelet-associated immunoglobulins (PAIgG, by ELISA), mean platelet volume (MPV), platelet distribution width (PDW), platelet-large cell ratio(P-LCR) by flow cytometry), and automated blood cytometer were tested in three groups of people patients with ITP (n=45), healthy people (n=45), and patients without ITP (n=42). Receiver operating characteristic (ROC) curve, LSD-t test, logistic regression, and correlation analysis were performed to identify the best indicators for diagnosing ITP.RESULTS:
The patients with ITP had higher levels of RP, MPV, PDW, P-LCR, and PAIgG than the healthy people and the patients without ITP (P<0.05). The patients without ITP had higher TPO than the healthy people and the patients with ITP (P<0.05). RP and PAIgG were sensitive indicators to ITP. PR was correlated to the diagnosis of ITP (chi2=10.458, P=0.001).CONCLUSION:
Individual indicator has limited diagnostic values for ITP, which could be improved by a combination of the indicators.
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Base de dados:
MEDLINE
Assunto principal:
Púrpura Trombocitopênica
/
Reticulócitos
/
Autoanticorpos
/
Plaquetas
/
Imunoglobulina G
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Female
/
Humans
/
Male
Idioma:
Zh
Ano de publicação:
2008
Tipo de documento:
Article