Reduction of prelimbic inhibitory gating of auditory evoked potentials after fear conditioning.
Behav Neurosci
; 123(2): 315-27, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19331455
ABSTRACT
Inhibitory gating (IG) is a basic central nervous system process for filtering repetitive sensory information. Although IG deficits coincide with cognitive and emotional dysfunction in a variety of neuropsychiatric disorders, limited research has been completed on the basic, functional nature of IG. Persistent IG occurs in rat prelimbic medial prefrontal cortex (mPFC), a crucial site for modulating emotional learning. To investigate the interaction of affect and IG, we recorded local field potentials (LFP) directly from prelimbic mPFC and examined the influence of tone-shock fear conditioning (FC) on IG. Behavioral reactions during IG were observed before and after FC, and increase of orienting response after FC indicated induction of tone-shock association. After FC, some components of LFP response exhibited short-term weakening of IG. On a subsequent day of recording, IG strengthened for all LFP components, but individual components differed in their particular changes. Affective regulation of IG represents an important factor influencing within-subject IG variability, and these results have implications for understanding the role of rapid, implicit neural coding involved in emotional learning and affective disruption in psychiatric disease.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Córtex Pré-Frontal
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Condicionamento Clássico
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Potenciais Evocados Auditivos
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Filtro Sensorial
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Medo
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Inibição Neural
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article