[Effects of systemic administration of glutamate antibodies on acute convulsive reaction of C57B1/6 mice].

The impact of a single intraperitoneal injection of antibodies to glutamate (AG) on acute generalized epileptic activity provoked by systemic introduction of pentilentetrasol was studied in C57B1/6 mice. It was found that AG in doses 10, 25 and 50 mg/kg 1.5 and 24 hours after AG injection produced an anti-epileptic action by raising thresholds of clonic convultions and tonic phase of convultions with lethal outcome and by extending a latent period of their appearance. Later (30 hours after antibodies introduction in a dose 25 mg/kg) AG had no effects on the convulsive reaction thresholds, 48 hours after AG injection they produced a proepileptic effect by lowering the threshold of a clonic convulsion phase.