Hepatoprotective activity of six polyherbal formulations in CCl4-induced liver toxicity in mice.
Indian J Exp Biol
; 47(4): 257-63, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19382721
ABSTRACT
To evaluate pretreatment of six polyherbal liquid formulations (PLFs) commercially available in India, on CCl4-induced liver injury, Swiss albino mice were treated for 7 days with distilled water or PLFs (2.6 and 5.2 ml/kg body weight/day, po) followed by single sc injection of 50% (v/v) CCl4 in arachis oil at a dose of 1 ml/kg. The serum biochemical parameters such as alanine transaminases, aspartate transaminases and alkaline phosphatase were estimated. Phenobarbitone-induced sleeping time and liver histopathology were also carried out. CCl4-treated animals showed significant increase in the levels of liver enzymes, phenobarbitone-induced sleeping time and revealed fatty changes and centrizonal necrosis on histological examination of liver indicating hepatic damage. When pretreated with PLFs at a dose of 5.2 ml/kg body weight/day, the CCl4-induced changes were significantly reversed. The pretreatment with PLFs can prevent acute liver damage induced by CCl4 only at a higher dose. Therefore, it is suggested that a dose adjustment of these PLFs may be necessary for their optimal effects in human liver diseases.
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Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Substâncias Protetoras
/
Fígado
/
Hepatopatias
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article