Effects of schisandrin on transcriptional factors in lipopolysaccharide-pretreated macrophages.
Arch Pharm Res
; 32(3): 399-405, 2009 Mar.
Article
em En
| MEDLINE
| ID: mdl-19387584
ABSTRACT
Schisandrin is the main active ingredient isolated from Schisandra chinensis Baill. Recent studies have demonstrated that schisandrin exhibits anti-inflammatory effects in vivo and in vitro. In this study, we examined whether the order of lipopolysaccharide (LPS) treatment affects the mechanism of schisandrin anti-inflammatory activity. We found that the antiinflammatory mechanisms are not the same depending on whether macrophages were treated with schisandrin before or after LPS. The main difference is that inhibitor kappaBalpha (IkappaBalpha) degradation was not inhibited when macrophages were pretreated by LPS before schisandrin and was weakly inhibited when macrophages were pretreated by schisandrin before LPS.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos Policíclicos
/
Fatores de Transcrição
/
Lipopolissacarídeos
/
Lignanas
/
Ciclo-Octanos
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Macrófagos
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Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article