[Expression of matrix metalloproteinase-3 after brain contusion in rats].
Fa Yi Xue Za Zhi
; 25(1): 1-5, 2009 Feb.
Article
em Zh
| MEDLINE
| ID: mdl-19397203
ABSTRACT
OBJECTIVE:
To investigate the expression of matrix metalloproteinase-3 after brain contusion and its applicability for estimating the age of brain contusion.METHODS:
Rats had been divided into three groups control group, sham operation group and brain contusion group. The expression of matrix metalloproteinase-3 at different time was detected by immunohistochemistry and Western blot.RESULTS:
By the immunohistochemistry, no staining was observed in control and sham operation groups. The positive staining of MMP-3 appeared 6 hours after contusion, increased gradually in 24 hours and peaked 5 days after contusion, then started to decrease, 14 days after contusion still could be observed. By the Western blot analysis, no expression of MMP-3 was detected in control and sham groups. The positive staining of MMP-3 appeared 6 hours after contusion, increased gradually and maximized 5 days after contusion, then started to decrease, 14 days after contusion still could be found.CONCLUSION:
Time-order expression of MMP-3 could be used for estimating the age of brain contusion in forensic pathology.
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Base de dados:
MEDLINE
Assunto principal:
Lesões Encefálicas
/
Metaloproteinase 3 da Matriz
/
Patologia Legal
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2009
Tipo de documento:
Article