Metal deposition in calcific uremic arteriolopathy.
J Am Acad Dermatol
; 61(1): 73-9, 2009 Jul.
Article
em En
| MEDLINE
| ID: mdl-19406504
ABSTRACT
BACKGROUND:
Calcific uremic arteriolopathy (CUA) is an often fatal disease that affects patients with end-stage renal disease. Although animal studies support a role for metals in the pathogenesis of CUA, metal accumulation in human tissue has not been previously evaluated.OBJECTIVE:
We sought to evaluate metal deposition in CUA.METHODS:
Twelve histologically proven cases of CUA were identified from our dermatopathology database. Five skin biopsy specimens from patients with chronic kidney disease exposed to gadolinium contrast but without CUA were used as controls. Quantification of metals including iron, aluminum, and gadolinium in the lesional skin was performed using inductively coupled mass spectrometry.RESULTS:
Seven patients had documented exposure to gadolinium-based contrast in the 2 years before CUA. Three of them had concurrent nephrogenic systemic fibrosis. Highly significant quantities of iron (P = .03) and aluminum (P = .0002) were detected in CUA specimens compared with controls. Significant amounts of gadolinium were present in several CUA biopsy specimens.LIMITATIONS:
Observational, retrospective study design and small sample size are limitations.CONCLUSION:
Tissue iron and aluminum content is increased in CUA. A significant amount of gadolinium is also present in some CUA specimens. Based on animal studies that strongly implicate metals in the pathogenesis of CUA, our data suggest that metal deposition should be considered in the pathogenesis of human CUA.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Arteriopatias Oclusivas
/
Calciofilaxia
/
Alumínio
/
Gadolínio
/
Ferro
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article