Chronic basophilic leukemia: a rare form of chronic myeloproliferative neoplasm.
Hum Pathol
; 40(8): 1194-9, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19427022
ABSTRACT
Chronic basophilic leukemia is a rare and poorly characterized entity. Only a limited number of cases have been described. Herein, we report a patient who presented with fatigue, weight loss, leukocytosis, persistent prominent basophilia, and mild eosinophilia. The bone marrow showed features characteristic of a myeloproliferative neoplasm with a marked increase in maturing basophils. The basophils exhibited nuclear hypersegmentation, abnormal granulation, and abnormally low CD38 expression. Conventional karyotyping revealed a t(5;12)(q31;p13). ETV6 but not PDGFRB rearrangement was detected by fluorescence in situ hybridization.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Basófilos
/
Leucemia Mieloide de Fase Crônica
Limite:
Aged80
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article