Hepatocyte growth factor-mediated attraction of mesenchymal stem cells for apoptotic neuronal and cardiomyocytic cells.
Cell Mol Life Sci
; 67(2): 295-303, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-19888551
ABSTRACT
Human bone marrow-derived mesenchymal stem cells (MSC) home to injured tissues and have regenerative capacity. In this study, we have investigated in vitro the influence of apoptotic and necrotic cell death, thus distinct types of tissue damage, on MSC migration. Concordant with an increased overall motility, MSC migrated towards apoptotic, but not vital or necrotic neuronal and cardiac cells. Hepatocyte growth factor (HGF) was expressed by the apoptotic cells only. MSC, in contrast, revealed expression of the HGF-receptor, c-Met. Blocking HGF bioactivity resulted in significant reduction of MSC migration. Moreover, recombinant HGF attracted MSC in a dose-dependent manner. Thus, apoptosis initiates chemoattraction of MSC via the HGF/c-Met axis, thereby linking tissue damage to the recruitment of cells with regenerative potential.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Regeneração
/
Movimento Celular
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Fator de Crescimento de Hepatócito
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Miócitos Cardíacos
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Células-Tronco Mesenquimais
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Neurônios
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article