Role of RNA structure in regulating pre-mRNA splicing.
Trends Biochem Sci
; 35(3): 169-78, 2010 Mar.
Article
em En
| MEDLINE
| ID: mdl-19959365
ABSTRACT
Pre-mRNA splicing involves removing non-coding introns from RNA transcripts. It is carried out by the spliceosome, along with other auxiliary factors. In general, research in splicing has focused on the sequences within the pre-mRNA, without considering the structures that these sequences might form. We propose that the role of RNA structure deserves more consideration when thinking about splicing mechanisms. RNA structures can inhibit or aid binding of spliceosomal components to the pre-mRNA, or can increase splicing efficiency by bringing important sequences into close proximity. Recent reports have identified proteins and small molecules that can regulate splicing by modulating RNA structures, thereby expanding our knowledge of the mechanisms used to regulate splicing.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA
/
Precursores de RNA
/
Splicing de RNA
/
Conformação de Ácido Nucleico
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article