Identification of novel chromosomal regions associated with airway hyperresponsiveness in recombinant congenic strains of mice.
Mamm Genome
; 21(1-2): 28-38, 2010 Feb.
Article
em En
| MEDLINE
| ID: mdl-20012967
ABSTRACT
Airway responsiveness is the ability of the airways to respond to bronchoconstricting stimuli by reducing their diameter. Airway hyperresponsiveness has been associated with asthma susceptibility in both humans and murine models, and it has been shown to be a complex and heritable trait. In particular, the A/J mouse strain is known to have hyperresponsive airways, while the C57BL/6 strain is known to be relatively refractory to bronchoconstricting stimuli. We analyzed recombinant congenic strains (RCS) of mice generated from these hyper- and hyporesponsive parental strains to identify genetic loci underlying the trait of airway responsiveness in response to methacholine as assessed by whole-body plethysmography. Our screen identified 16 chromosomal regions significantly associated with airway hyperresponsiveness (genome-wide P
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hipersensibilidade Respiratória
/
Sistema Respiratório
/
Cromossomos de Mamíferos
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article