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Regioselective intramolecular dipolar cycloaddition of azides and unsymmetrical alkynes.
Brawn, Ryan A; Welzel, Morgan; Lowe, Jason T; Panek, James S.
Afiliação
  • Brawn RA; Department of Chemistry and Center for Chemical Methodology and Library Development, Metcalf Center for Science and Engineering, 590 Commonwealth Avenue, Boston University, Boston, Massachusetts 02215, USA.
Org Lett ; 12(2): 336-9, 2010 Jan 15.
Article em En | MEDLINE | ID: mdl-20017521
Enantioenriched allenylsilanes are used in three-component propargylation reactions with aldehydes and silyl ethers to form syn-homopropargylic ethers that contain an imbedded azide. These materials then undergo thermally induced intramolecular 1,3-dipolar cycloaddition reactions, resulting in unique fused ring systems containing 1,2,3-triazoles. The ability to modify all three components of the reaction allows for expedient access to compounds containing significant structural and stereochemical variation.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Azidas / Alcinos Idioma: En Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Azidas / Alcinos Idioma: En Ano de publicação: 2010 Tipo de documento: Article