Regioselective intramolecular dipolar cycloaddition of azides and unsymmetrical alkynes.
Org Lett
; 12(2): 336-9, 2010 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-20017521
Enantioenriched allenylsilanes are used in three-component propargylation reactions with aldehydes and silyl ethers to form syn-homopropargylic ethers that contain an imbedded azide. These materials then undergo thermally induced intramolecular 1,3-dipolar cycloaddition reactions, resulting in unique fused ring systems containing 1,2,3-triazoles. The ability to modify all three components of the reaction allows for expedient access to compounds containing significant structural and stereochemical variation.
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1
Base de dados:
MEDLINE
Assunto principal:
Azidas
/
Alcinos
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article