Repression of Fgf signaling by sprouty1-2 regulates cortical patterning in two distinct regions and times.
J Neurosci
; 30(11): 4015-23, 2010 Mar 17.
Article
em En
| MEDLINE
| ID: mdl-20237272
ABSTRACT
A fundamental question in developmental biology is how signaling pathways establish a transcription factor code that controls cell proliferation, regional fate and cell fate. Morphogenesis of the rostral telencephalon is controlled in part by Fgf signaling from the rostral patterning center. How Fgf signaling is regulated in the telencephalon is critical for understanding cerebral cortex formation. Here we show that mouse Sprouty1 and Sprouty2 (Spry1-2), which encode negative feedback regulators of Fgf signaling, are affecting cortical proliferation, differentiation, and the expression of genes regulating progenitor identity in the ventricular zone. In addition, Spry2 has a later function in regulating the MAPK pathway, proliferation, and gene expression in the cortex at mid-neurogenesis. Finally, we provide evidence that Coup-TFI, a transcription factor that promotes caudal fate, does so through repressing Fgf signaling, in part by promoting Spry expression.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fosfoproteínas
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Transdução de Sinais
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Córtex Cerebral
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Ventrículos Cerebrais
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Padronização Corporal
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Fatores de Crescimento de Fibroblastos
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Proteínas de Membrana
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article