Malonaldehyde formation and DNA fragmentation: two independent sperm decays linked to reactive oxygen species.
Zygote
; 18(3): 265-8, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-20331908
ABSTRACT
Malondialdehyde (MDA), a product involved in membrane lipid peroxidation, was dosed in the sperm of 163 patients who had consulted the clinic regarding hypofertility. We attempted to determine if there was correlation between MDA content, sperm World Health Organization parameters and DNA fragmentation that results mainly from reactive oxygen species assaults. We found that no correlation could be established; however MDA and sperm decondensation were shown to be significantly linked. The impact of membrane polyunsaturated fatty acids and the role of phospholipid hydroperoxide glutathione peroxidase are discussed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Espermatozoides
/
Espécies Reativas de Oxigênio
/
Fragmentação do DNA
/
Glutationa Peroxidase
/
Malondialdeído
Limite:
Humans
/
Male
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article