Family study of restless legs syndrome in Quebec, Canada: clinical characterization of 671 familial cases.
Arch Neurol
; 67(5): 617-22, 2010 May.
Article
em En
| MEDLINE
| ID: mdl-20457962
ABSTRACT
OBJECTIVES:
To fully ascertain the familial aggregation of restless legs syndrome (RLS) and to characterize the clinical features of familial RLS (fRLS) cases.DESIGN:
A case series survey with a high response rate.SETTING:
Academic research center.PARTICIPANTS:
Consecutive RLS probands (n = 249) were followed up in a specialized sleep center for 15 years. A total of 671 cases of fRLS met the current standard diagnostic criteria, including 192 probands characterized using multidimensional clinical assessments and 479 affected family members assessed by their responses to a structured questionnaire telephone diagnostic interview. MAIN OUTCOMEMEASURES:
Sibling and offspring relative risk ratio and clinical and genetic features of patients with fRLS and families.RESULTS:
Our data showed that RLS aggregates in families with a familial rate of 77%, a sibling relative risk of 3.6 (95% confidence interval, 2.8-4.4), and an offspring relative risk of 1.8 (1.0-2.7). Familial RLS is a chronic disorder with a mean (SD) disease duration of 24 (16) years and a wide range of age of onset (mean [SD], 28 [15] years), with most family members having early-onset disease but mild to moderate RLS symptoms. Our clinical data also indicated that fRLS is more prominent among women who also had increased incidence of anemia/iron deficiency, arthritis, and number of pregnancies. Pregnancy-related RLS seems to be a characteristic feature of fRLS, and afflicted women tend to have a much younger age of onset.CONCLUSIONS:
Restless legs syndrome significantly aggregated in families with variable phenotypic expressivity, and the siblings of severely affected individuals have an increased risk of developing the disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome das Pernas Inquietas
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Predisposição Genética para Doença
Tipo de estudo:
Etiology_studies
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Qualitative_research
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article