Identification of human idiotype-specific T cells in lymphoma and myeloma.
Curr Top Microbiol Immunol
; 344: 193-210, 2011.
Article
em En
| MEDLINE
| ID: mdl-20549471
ABSTRACT
Idiotype protein, among the first identified tumor-specific antigens, has been found to stimulate both humoral and cellular responses in lymphoma and myeloma patients. With the increasing use of B cell depletion treatments such as rituximab in clinic, the cellular response mediated by idiotype-specific T cells has become increasingly important as an adjunct therapy for lymphoma and myeloma. Here, we review the idiotype protein as a tumor antigen and the characteristics of the T cell response elicited idiotype vaccination. We also analyze the T cell epitopes that have been identified in idiotype protein and introduce our new findings of additional T cell epitopes derived from the Ig light chain. Finally, we propose new directions in the generation of idiotype-specific T cells for tumor therapy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Idiótipos de Imunoglobulinas
/
Linfoma
/
Mieloma Múltiplo
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article