Chromosome locations of the MYB related genes, AMYB and BMYB.
Cancer Res
; 51(14): 3821-4, 1991 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-2065336
ABSTRACT
The MYB related loci, AMYB and BMYB, were localized to specific human chromosome regions by Southern blot analysis of their segregation patterns in a panel of rodent-human hybrid DNAs using radiolabeled AMYB and BMYB probes. The AMYB locus was present in hybrids retaining the chromosome region 8cen----8q22 and was absent in hybrids which had lost this chromosome region. The presence of the BMYB locus in rodent-human hybrids correlated with, and only with, chromosome region Xq13. Chromosomal in situ hybridization refined the localization of AMYB to region 8q22-23 and confirmed the localization of BMYB to region Xq13. Chromosome region 8q22 is involved in recurrent translocations in malignant lymphoma and in acute myeloid leukemia (AML-M2); therefore AMYB is a candidate for involvement in such translocations. A region on Xq13 is also involved in chromosomal abnormalities in acute myeloid leukemia and myelodysplasias.
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Base de dados:
MEDLINE
Assunto principal:
Proto-Oncogenes
/
Mapeamento Cromossômico
/
Proteínas Proto-Oncogênicas
Limite:
Humans
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article