[L-carnitine: safe and effective for asthenozoospermia].
Zhonghua Nan Ke Xue
; 16(5): 420-2, 2010 May.
Article
em Zh
| MEDLINE
| ID: mdl-20684322
ABSTRACT
OBJECTIVE:
One of the important reasons for male infertility is asthenozoospermia, for which there is no specific cure for the time being. The authors explored the clinical effect of L-carnitine for infertile males with asthenozoospermia.METHODS:
A total of 135 patients with asthenozoospermia were randomly divided into Groups A (n = 68) and B (n = 67), the former treated with L-carnitine (2 g/d) and vitamin E, while the latter with vitamin E only, both for 3 months. All the patients received semen analyses before and after the treatment, and were observed for adverse effects. The pregnancy rates of their wives were recorded.RESULTS:
Group A showed a significantly increased percentage of forward motile sperm after the treatment (45.4% +/- 11.1%) as compared with pretreatment (28.6% +/- 9.2%) (P < 0.01), but no statistically significant differences were found in sperm density and the percentage of the sperm of normal morphology (P > 0.05). The rate of pregnancy was significantly higher in Group A (31.1%) than in B (3.8%) after the treatment (P < 0.01). No adverse events were found during the treatment.CONCLUSION:
L-carnitine, capable of significantly improving sperm motility and raising the rate of pregnancy, is a safe and effective therapeutic option for asthenozoospermia.
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Base de dados:
MEDLINE
Assunto principal:
Vitamina E
/
Carnitina
/
Astenozoospermia
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
Idioma:
Zh
Ano de publicação:
2010
Tipo de documento:
Article