Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells.
FEBS Lett
; 267(1): 16-8, 1990 Jul 02.
Article
em En
| MEDLINE
| ID: mdl-2114322
ABSTRACT
We have investigated the effect of glucose on the release of endothelin-1-like immunoreactivity (ET-1-LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET-1-LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose-induced ET-1-LI release. These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET-1-LI release at the local site of vascular endothelium, which might be involved in the developments of vascular complications and atherosclerosis.
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Base de dados:
MEDLINE
Assunto principal:
Aorta
/
Peptídeos
/
Glucose
Limite:
Animals
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article