SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma.
Blood
; 117(11): 3147-50, 2011 Mar 17.
Article
em En
| MEDLINE
| ID: mdl-21233317
ABSTRACT
Inherited risk determinants for follicular lymphoma (FL) have recently been described in the immune gene-rich human leukocyte antigen region on chromosome 6p. The known importance of host immune response to FL survival led us to evaluate these germline factors in FL outcome. We confirm the association of single nucleotide polymorphisms rs10484561 (P = 3.5 × 10â»9) and rs6457327 (P = .008) with risk of FL and demonstrate that rs6457327 predicts both time to (P = .02) and risk of (P < .01) FL transformation independently of clinical variables, including the Follicular Lymphoma International Prognostic Index.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 6
/
Transformação Celular Neoplásica
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Linfoma Folicular
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Polimorfismo de Nucleotídeo Único
/
Antígenos HLA
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article