Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells.
Bioorg Med Chem Lett
; 21(4): 1279-81, 2011 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-21273070
ABSTRACT
A new pyrrolidinone diterpenoid, excisusin F (1), was isolated from the aerial parts of Isodon excisus (Lamiaceae), together with four known compounds, and their structures were determined mainly by NMR (1D and 2D) and mass spectrometry. Excisusin F (1) and inflexarabdonin E (3) showed potent inhibitory effects of LPS-induced nitric oxide production in RAW264.7 cells with the IC(50) value of 10.4 and 3.8 µM, respectively.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirrolidinonas
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Isodon
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Diterpenos
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Macrófagos
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Óxido Nítrico
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article