Pre-treatment predictors of response for assessing outcomes to standard treatment in infection with HCV genotype 3.
J Coll Physicians Surg Pak
; 21(2): 64-8, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21333234
ABSTRACT
OBJECTIVE:
To determine the role of pre-treatment predictors of response in assessing outcomes to standard treatment in HCV genotype 3. STUDYDESIGN:
Observational study. PLACE AND DURATION OF STUDY Department of Medicine, KRL General Hospital, Islamabad, from December 2004 to December 2006.METHODOLOGY:
All patients with positive anti-HCV and PCR genotype 3a were recruited and written and informed consent was taken. Patients were treated with standard Interferon plus Ribavirin therapy (IFN alpha-2a, 3MU t.i.w 24 weeks plus Ribavirin 1000-1200 mg/day) for 6 months. The effect of pre-treatment factors influencing outcome i.e. age, gender, weight, baseline ALT, necroinflammatory grade, fibrosis and steatosis on the final outcome were further analyzed by univariate logistic regression analysis.RESULTS:
Response rates to standard Interferon plus Ribazole therapy were studied in 190 patients. The end-of-treatment complete response (EOTCR) was seen in 81% (n=155) of the patients, whereas 17% (n=33) were non-responders (NR). Sustained viral response (SVR) was seen in 58% (n=112) patients and 24% (n=45) were relapsers. SVR was higher in patients without steatosis (OR=2.52, 95% CI=1.356- 4.71, p=0.04). Higher SVR was seen in patients weighing less than 65 kg, as compared with weight>65 kg (OR=2.277, 95% CI=1.246-4.161, p=0.007). The other variables were not found to be significantly associated with improved SVRs.CONCLUSION:
Out of the studied predictors, body weight and presence of steatosis, were statistically related to treatment outcome. Pre-treatment host factors can predict response to treatment that can help in individualizing treatment and patient selection and optimize treatment outcomes.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Hepacivirus
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Hepatite C Crônica
Tipo de estudo:
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article