The ABC transporters in lipid flux and atherosclerosis.
Prog Lipid Res
; 50(3): 213-24, 2011 Jul.
Article
em En
| MEDLINE
| ID: mdl-21352852
ABSTRACT
Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality in the United States and in many other countries. Dysfunctional lipid homeostasis plays a central role in the initiation and progression of atherosclerotic lesions. The ATP-binding cassette (ABC) transporters are transmembrane proteins that hydrolyze ATP and use the energy to drive the transport of various molecules across cell membranes. Several ABC transporters play a pivotal role in lipid trafficking. They are critically involved in cholesterol and phospholipid efflux and reverse cholesterol transport (RCT), processes that maintain cellular cholesterol homeostasis and protect arteries from atherosclerosis. In this article we provide a review of the current literature on the biogenesis of ABC transporters and highlight their proposed functions in atheroprotection.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Colesterol
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Transportadores de Cassetes de Ligação de ATP
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Aterosclerose
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Metabolismo dos Lipídeos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article