3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: design and development to a highly selective lead.
Bioorg Med Chem Lett
; 21(11): 3452-6, 2011 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-21515047
ABSTRACT
Learnings from previous Roche p38-selective inhibitors were applied to a new fragment hit, which was optimized to a potent, exquisitely selective preclinical lead with a good pharmacokinetic profile.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Desenho de Fármacos
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Proteína Quinase 14 Ativada por Mitógeno
/
Ativação Enzimática
/
Inibidores Enzimáticos
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article