Defective GATA-3 expression in Th2 LCR-deficient mice.
Biochem Biophys Res Commun
; 410(4): 866-71, 2011 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-21703230
ABSTRACT
Th2 cell differentiation is critically influenced by transcription factor GATA-3 and by various cis-acting elements including enhancers, silencers and a locus control region (LCR) in the Th2 cytokine locus. Th2 LCR-deficient Th2 cells completely lost the expression of GATA-3 and the phosphorylation of STAT6. Histone 3 lysine 4 (H3-K4) was hypomethylated in the gata3 locus in these cells. GATA-3 and STAT6 bound several regulatory regions in the gata3 locus and transactivated the expression of the gata3 gene. These results suggest that Th2 differentiation program stimulates feed-forward regulation of gata3 gene expression.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Diferenciação Celular
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Ativação Transcricional
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Células Th2
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Região de Controle de Locus Gênico
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Fator de Transcrição GATA3
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article