[Role of histone modifications in differentiation and effector function of CD8 T cells: update review including genome-wide analysis].
Nihon Rinsho Meneki Gakkai Kaishi
; 34(3): 131-7, 2011.
Article
em Ja
| MEDLINE
| ID: mdl-21720101
ABSTRACT
Evidence including genome-wide analyses have uncovered that epigenetic mechanisms regulate differentiation and effector functions in CD8 T cells. Gene expression profiles change when CD8 T cells differentiate from naïve T cells to memory T cells. It has been shown that this programmed differentiation is regulated by epigenetic mechanisms. Upon antigen stimulation, CD8 T cells activate and acquire effector functions to target cells. Effector molecule gene expressions are upregulated by epigenetic mechanisms in CD8 T cells. It is suggested that memory T cells respond more rapidly to antigens because chromatin structures of effector molecule genes are open and their gene transcriptions are poised for activation.
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Base de dados:
MEDLINE
Assunto principal:
Histonas
/
Linfócitos T
/
Diferenciação Celular
/
Antígenos CD8
/
Estudo de Associação Genômica Ampla
Limite:
Animals
/
Humans
Idioma:
Ja
Ano de publicação:
2011
Tipo de documento:
Article