Simultaneous analysis of tumor and stromal gene expression profiles from xenograft models.
Breast Cancer Res Treat
; 131(1): 321-4, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-21947683
ABSTRACT
Identifying the gene expression alterations that occur in both the tumor and stroma is essential to understanding tumor biology. We have developed a dual-species microarray analysis method that allows the dissection of both tumor and stromal gene expression profiles from xenograft models, based on limited interspecies cross-hybridization on Illumina gene expression beadchips. This methodology allows for simultaneous genome-wide analysis of gene expression profiles of both tumor cells and the associated stromal tissue.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Células Estromais
/
Perfilação da Expressão Gênica
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article