Anti-microRNA-222 (anti-miR-222) and -181B suppress growth of tamoxifen-resistant xenografts in mouse by targeting TIMP3 protein and modulating mitogenic signal.

Lu, Yuanzhi; Roy, Satavisha; Nuovo, Gerard; Ramaswamy, Bhuvaneswari; Miller, Tyler; Shapiro, Charles; Jacob, Samson T; Majumder, Sarmila

Lu, Yuanzhi; Roy, Satavisha; Nuovo, Gerard; Ramaswamy, Bhuvaneswari; Miller, Tyler; Shapiro, Charles; Jacob, Samson T; Majumder, Sarmila.

Afiliação

Lu Y; Departments of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210; Department of Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210.
Roy S; Departments of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210.
Nuovo G; Department of Pathology, The Ohio State University, Columbus, Ohio 43210.
Ramaswamy B; Department of Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210; Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210.
Miller T; Departments of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210.
Shapiro C; Department of Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210; Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210.
Jacob ST; Departments of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210; Department of Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210; Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210. Electronic address: Samso
Majumder S; Departments of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210; Department of Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210. Electronic address: Sarmila.majumder@osumc.edu.

J Biol Chem ; 286(49): 42292-42302, 2011 Dec 09.

Article em En | MEDLINE | ID: mdl-22009755

Assuntos

Antineoplásicos Hormonais/farmacologia; Neoplasias da Mama/metabolismo; Regulação Neoplásica da Expressão Gênica; Neoplasias Mamárias Animais/metabolismo; MicroRNAs/metabolismo; Tamoxifeno/farmacologia; Inibidor Tecidual de Metaloproteinase-3/fisiologia; Animais; Neoplasias da Mama/genética; Linhagem Celular Tumoral; Movimento Celular; Proliferação de Células; Regulação para Baixo; Feminino; Humanos; Peptídeos e Proteínas de Sinalização Intercelular/metabolismo; Neoplasias Mamárias Animais/genética; Metaloproteases/metabolismo; Camundongos; Transplante de Neoplasias; Cicatrização

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tamoxifeno / Neoplasias da Mama / Regulação Neoplásica da Expressão Gênica / Neoplasias Mamárias Animais / Antineoplásicos Hormonais / Inibidor Tecidual de Metaloproteinase-3 / MicroRNAs Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2011 Tipo de documento: Article

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