Chemical composition and in vitro schistosomicidal activity of the essential oil of Plectranthus neochilus grown in Southeast Brazil.
Chem Biodivers
; 8(11): 2149-57, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-22083928
ABSTRACT
The chemical composition and the in vitro schistosomicidal effects of the essential oil of Plectranthus neochilus (PN-EO) grown in Southeast Brazil was studied. ß-Caryophyllene (1; 28.23%), α-thujene (2; 12.22%), α-pinene (3; 12.63%), ß-pinene (4; 6.19%), germacrene D (5; 5.36%), and caryophyllene oxide (6; 5.37%) were the major essential oil constituents. This chemical composition differed from that previously reported for specimens harvested in Africa. Concerning the in vitro schistosomicidal activity against adult Schistosoma mansoni worms, PN-EO was considered to be active, but less effective than the positive control praziquantel (PZQ) in terms of separation of coupled pairs, mortality, decrease in the motor activity, and tegumental alterations. However, PN-EO caused an interesting dose-dependent reduction in the number and the percentage of developed S. mansoni eggs. These results suggest that PN-EO might be very promising for the development of new schistosomicidal agents.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esquistossomicidas
/
Óleos de Plantas
/
Óleos Voláteis
/
Plectranthus
Limite:
Animals
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article