p53 serves as a host antiviral factor that enhances innate and adaptive immune responses to influenza A virus.
J Immunol
; 187(12): 6428-36, 2011 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-22105999
ABSTRACT
Several direct target genes of the p53 tumor suppressor have been identified within pathways involved in viral sensing, cytokine production, and inflammation, suggesting a potential role of p53 in antiviral immunity. The increasing need to identify immune factors to devise host-targeted therapies against pandemic influenza A virus (IAV) led us to investigate the role of endogenous wild-type p53 on the immune response to IAV. We observed that the absence of p53 resulted in delayed cytokine and antiviral gene responses in lung and bone marrow, decreased dendritic cell activation, and reduced IAV-specific CD8(+) T cell immunity. Consequently, p53(-/-) mice showed a more severe IAV-induced disease compared with their wild-type counterparts. These findings establish that p53 influences the antiviral response to IAV, affecting both innate and adaptive immunity. Thus, in addition to its established functions as a tumor suppressor gene, p53 serves as an IAV host antiviral factor that might be modulated to improve anti-IAV therapy and vaccines.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Regulação Viral da Expressão Gênica
/
Proteína Supressora de Tumor p53
/
Infecções por Orthomyxoviridae
/
Vírus da Influenza A Subtipo H1N1
/
Vírus da Influenza A Subtipo H3N2
/
Proteínas Virais Reguladoras e Acessórias
/
Imunidade Adaptativa
/
Imunidade Inata
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article