Alterations in the expression of translation factors as molecular markers in cadmium-exposed workers.
Biomarkers
; 17(1): 78-84, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-22149723
ABSTRACT
Eukaryotic translation initiation factor 3 (eIF3) and elongation factor 1δ (eEF-1δ) are novel cadmium (Cd) responsive proto-oncogenes. This research investigated the expression of these genes in Cd-exposed workers (n = 58), and to evaluate their usefulness as biomarkers of Cd exposure. According to urinary Cd concentration, the subjects were divided into four groups (urinary Cd concentration ≥0.1 µg/g.Cr, ≥1.0 µg/g.Cr, ≥5.0 µg/g.Cr and ≥50.0 µg/g.Cr). Subjects exhibited increased severe health problems with higher urinary Cd concentrations. The eIF3 and eEF-1δ expression in the blood were investigated with real-time PCR. PCR data showed a strong positive correlation between blood eEF-1δ and urinary Cd concentrations (r = 0.788, p < 0.01), and a weak positive correlation between blood eIF3 expression and urinary Cd concentrations (r = 0.569, p < 0.05). These findings, for the first time, demonstrate that the blood eEF-1δ overexpression can be used as a molecular biomarker of Cd-exposed population.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cádmio
/
Faringite
/
Exposição Ocupacional
/
Fator 1 de Elongação de Peptídeos
/
Doenças Profissionais
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article