[Percutaneous permeability study for patches Shangshi Zhitong on different kinds of bases].

OBJECTIVE: To study the percutaneous permeability of patches Shangshi Zhitong on different kinds of bases with the permeation percentage of brucine, strychnine and atropine. METHOD: Using modified Franz difusion to investigate the penetration quantity of brucine, strychnine and atropine. The contents of brucine, strychnine and atropine were determined by HPLC. RESULT: The average accumulative permeation percentage of brucine, strychnine and atropine on new base were 53.25%, 74.52% were 34.32%, respectively, and on old base are 54.90%, 50.24%, 46. 54%, respectively. CONCLUSION: The new base benefits the lipophilic drugs and releases more stably.