SCN1A mutations in Dravet syndrome: impact of interneuron dysfunction on neural networks and cognitive outcome.
Epilepsy Behav
; 23(3): 177-86, 2012 Mar.
Article
em En
| MEDLINE
| ID: mdl-22341965
ABSTRACT
Dravet syndrome (DS) is a childhood disorder associated with loss-of-function mutations in SCN1A and is characterized by frequent seizures and severe cognitive impairment. Animal studies have revealed new insights into the mechanisms by which mutations in this gene, encoding the type I voltage-gated sodium channel (Na(v)1.1), may lead to seizure activity and cognitive dysfunction. In this review, we further consider the function of fast-spiking GABAergic neurons, one cell type particularly affected by these mutations, in the context of the temporal coordination of neural activity subserving cognitive functions. We hypothesize that disruptions in GABAergic firing may directly contribute to the poor cognitive outcomes in children with DS, and discuss the therapeutic implications of this possibility.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Canais de Sódio
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Epilepsias Mioclônicas
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Transtornos Cognitivos
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Neurônios GABAérgicos
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Mutação
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Proteínas do Tecido Nervoso
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article