Nasal epithelium integrity, environmental stressors, and allergic sensitization: a biomarker study in adolescents.
Biomarkers
; 17(4): 309-18, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22424574
ABSTRACT
Changes in the airways epithelium caused by environmental insults might play a role in the development of allergic rhinitis. We measured albumin and Clara cell protein (CC16) in the nasal lavage fluid (NALF) from 474 adolescents (263 girls and 211 boys). The NALF CC16/albumin ratio, integrating the permeability and cellular integrity of the nasal epithelium, decreased mostly with time spent in chlorinated pools. In boys, a lower CC16/albumin ratio in NALF was associated with an increased risk of house dust mite sensitization. The results suggest that the CC16/albumin ratio in NALF can be used to detect nasal epithelium alterations linked to allergic sensitization.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Uteroglobina
/
Exposição Ambiental
/
Hipersensibilidade
/
Mucosa Nasal
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
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Animals
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Female
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Humans
/
Male
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article