Efficient chiral monophosphorus ligands for asymmetric Suzuki-Miyaura coupling reactions.
Org Lett
; 14(9): 2258-61, 2012 May 04.
Article
em En
| MEDLINE
| ID: mdl-22497425
ABSTRACT
A series of novel P-chiral monophosphorus ligands exhibit efficiency in asymmetric Suzuki-Miyaura coupling reactions, enabling the construction of an array of chiral biaryl products in high yields and excellent enantioselectivities (up to 96% ee) under mild conditions. The carbonyl-benzooxazolidinone moiety in these chiral biaryl products allows facile derivatization for further synthetic applications. A computational study has revealed that a π-π interaction between the two coupling partners can enhance the enantioselectivity of the coupling reaction.
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Base de dados:
MEDLINE
Assunto principal:
Compostos Organofosforados
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Paládio
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Benzoxazóis
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article